My home is in the heart of downtown, one block from Union Square (100 pt walk score!).
You're close to almost every subway line, restaurants, bars, entertainment & shops but have a beautiful, well-lit, fully air-conditioned oasis to retreat home to at the end of the day.
The street I live on is quiet with a few lovely cafes and the best grilled cheese sandwiches I've ever had and the apartment building is new w/ a private courtyard to enjoy a morning coffee or evening cocktail!
Only two rules:
1) Do not tell anyone you are staying with AirBnB, if anyone asks, tell them you are staying at a friend's place (mine!)
2) This is my home, please treat it as you would your own.